Tradename

Enivar, Энивар

International non-proprietary name

Complex medicine

Compound

Each effervescent tablet contains:

Active substances:

Taurine 500.00 mg,

Caffeine 30.00 mg,

Pantothenic acid 4.500 mg, Niacin 18.00 mg,

Vitamin B 2 1.2 mg, Vitamin B 6 3.25 mg, Vitamin B 12 4.5 mcg, Folate 75.00 mcg.

Excipients Q . S. _

Colour: chocolate brown.

Taste: cola.

Dosage form Effervescent tablets.

Pharmacotherapeutic group Metabolic agent, Vitamins.

Pharmacological properties

Taurine is a natural metabolic product of sulfur-containing amino acids: cysteine, cysteamine, methionine. Taurine has osmoregulatory and membrane-protective properties, has a positive effect on the phospholipid composition of cell membranes, and normalizes the exchange of calcium and potassium ions in cells. At taurine identified properties brake neurotransmitter, it has an anti-stress effect, can regulate release GABA, adrenaline prolactin and other hormones a also regulate answers on the them.

Participating in the synthesis of respiratory chain proteins in mitochondria, taurine regulates oxidative processes and exhibits antioxidant properties, affects enzymes.

Improves metabolic processes in heart, liver and other organs and tissues. In chronic diffuse liver diseases, it increases blood flow and reduces the severity of cytolysis. With cardiovascular insufficiency, it leads to a decrease in congestion in the small and large circles of blood circulation: declining intracardiac diastolic pressure, rises contractility myocardium (maximum speed cuts and relaxation, indices contractility and relaxation). Moderately reduces HELL at patients With arterial hypertension and practically not affects on the his level at patients with cardiovascular insufficiency with low blood pressure. Increases performance during heavy physical exertion. In diabetes mellitus, approximately 2 weeks after the start of taurine use, the concentration decreases glucose in blood. Noticed also significant a decrease in the concentration of triglycerides, to a lesser extent - the concentration of cholesterol, a decrease in the atherogenicity of plasma lipids. With long-term use (about 6 months) noted improvement microcirculatory blood flow eyes.

Caffeine - methylxanthine, which has a psychostimulant and analeptic Effect. competitive blocks central and peripheral A1 and A2 adenosine receptors. Inhibits PDE activity in the central nervous system, heart, smooth muscle organs, skeletal muscles fatty fabrics, promotes accumulation they contain cAMP and cGMP (this effect is observed when application only high doses caffeine). Stimulates centers medulla oblongata (respiratory and vasomotor), and also center n . vagus , has a direct excitatory effect on the cerebral cortex. Increases mental and physical performance, stimulates mental activity, motor activity, shortens time reactions, temporarily reduces fatigue and drowsiness. Accelerates and deepens breathing, usually has a positive foreign-, chrono-, batmo- and dromotropic Effect. Stimulates vasomotor center and has a direct relaxing effect on the vascular wall, which leads to the expansion of the vessels of the heart, skeletal muscles and kidneys, while the tone of the cerebral arteries rises (calls constriction cerebral vessels, which is accompanied by a decrease in cerebral blood flow and pressure oxygen in head brain). HELL changes under the influence of vascular and cardiac mechanisms of caffeine influence: caffeine does not change in normal initial blood pressure or slightly raises his, at arterial hypotension normalizes his. Renders antispasmodic action on smooth muscles (including bronchodilating effect), on striated - stimulating. Raises secretory gastric activity and diuresis (decreased reabsorption of Na + and water in the proximal and distal renal tubules, as well as vasodilation of the kidneys and increased filtration in the renal glomeruli). Reduces aggregation platelets and release of histamine from mast cells. Increases basal metabolism: increases glycogenolysis, raises lipolysis.

Pantothenic acid (calcium pantothenate). In the body, pantothenic acid is part of coenzyme A , which plays important role in processes acetylation and oxidation. Pantothenic acid is involved in carbohydrate and fat metabolism and the synthesis of acetylcholine. It is contained in significant amounts in the adrenal cortex and stimulates the formation of corticosteroids. Activates metabolic processes in tissues, improves the energy supply of the contractile function of the myocardium, improves processes regeneration.

Niacin (nicotinamide) normalizes inhibitory processes in the central nervous system, a also reduces manifestations of neurosis, hysteria, improves metabolism in the heart muscle, reinforces contractile ability hearts, normalizes blood circulation, expands small blood vessels. Essential for normal blood clotting. At deficit or absence nicotinamide in food develops pellagra.

Vitamin IN 2 (riboflavin) substrate activates synthesis flavin coenzymes interacts With ATP forms flavin mononucleotide and flavin adenine dinucleotide involved in the transfer protons and regulation redox telnyh processes. Plays an important role in metabolism in processes growth. Supports process phagocytosis, affects on the morphology and function central and autonomic nervous system, plays an important role in maintaining the normal visual function of the eye and in the synthesis erythropoietin, hemoglobin. Several raises secretory stomach function (participates in education hydrochloric acids gastric juice), improves bile secretion, facilitates the absorption of carbohydrates in the small intestine, is necessary to maintain normal microflora intestines. Promotes improvement of glycogen-fixing, synthetic, antitoxic function of the liver, increases the sensitivity of liver cells to action insulin promotes increments insulin. Normalizes level bilirubin in blood (hepatitis BUT).

Vitamin B6 _ (pyridoxine hydrochloride) plays important role in exchange substances. Required for normal functioning central and peripheral nervous systems. AT phosphorylated form, pyridoxine is a coenzyme of a large number of enzymes that act on the non-oxidative exchange amino acids (in including on the processes decarboxylation, transamination). Vitamin B 6 is involved in the metabolism of tryptophan, methionine, cysteine, glutamine and other amino acids. plays important role in exchange histamine. Promotes normalization lipid exchange.

Vitamin B12 _ (cyanocobalamin), applies to group water soluble vitamins. Possesses high biological activity. Necessary for normal hematopoiesis (promotes the maturation of red blood cells). Participates in the processes of transmethylation, hydrogen transfer, formation methionine, nucleic acids, choline, creatine. Promotes the accumulation in erythrocytes of compounds containing sulfhydryl groups. Has a beneficial effect on function liver and nervous systems. Participates in synthesis myelin sheath, stimulates hematopoiesis, reduces pain, related With defeat peripheral nervous system, stimulates nucleic acid metabolism through the activation of folic acids. Activates clotting system blood, in high doses causes promotion activity thromboplastin and prothrombin.

Folate (folic acid) is reduced in the body to tetrahydrofolic acid, which is a coenzyme involved in in various metabolic processes. Required for normal maturation megaloblasts and education normoblasts. Stimulates erythropoiesis, involved in synthesis of amino acids (including methionine, serine), nucleic acids, purines and pyrimidines, in the metabolism of choline, histidine. During pregnancy, it protects the body from the action of teratogenic factors. Contributes to the normal maturation and functioning of the placenta.

Indications for use

To increase efficiency, reduce fatigue and drowsiness at elevated mental and physical loads, decline forces for receiving additional energy.

Contraindications

Individual intolerance to the components, severe forms organic diseases CCC, glaucoma, irritability, old age, pregnancy, breastfeeding, children in age before eighteen years.

Dosage and administration

inside, on one tablet one once in day, previously dissolving in 200 ml water room temperature. Accept in daytime time.

Special instructions and precautions

Do not exceed the recommended dose. Take with caution persons suffering elevated nervous excitability, insomnia, arterial hypertension, angina pectoris, glaucoma, severe atherosclerosis.

Use during pregnancy and during breastfeeding

because of absence clinical research, confirming safety, the use of the drug during pregnancy is possible only on prescription, after assessing the benefit / risk ratio.

Not