TRILLO [Gentamicin + Clotrimazole + Dexamethasone] 2.5% Topical Cream

Instructions for the medical use of the medicinal product

TRILLO

Tradename

Trillo, Трилло

International non-proprietary name or generic name

Dexametasone+Gentamisin+Clotrimazole, Дексаметазон+Гентамицин+Клотримазол

Composition

Each 1 g of cream contains: Dexamethasone acetate BP 0.4 mg,

Gentamicin sulfate BP equiv. Gentamicin 1 mg, Clotrimazole BP 10 mg, Cream base q.s.

Dosage form

Cream for external use.

Pharmacotherapeutic group

Anti-inflammatory, antibacterial, antifungal agent.

Pharmacological properties

The combined drug has anti-inflammatory, anti-allergic, antibacterial and antifungal (fungicidal) effects.

Dexamethasone has an anti-inflammatory, anti-allergic effect.

Interacts with specific cytoplasmic glucocorticosteroid receptors to form a complex that induces the formation of proteins, ultimately inhibiting the release of arachidonic acid, which inhibits the synthesis of substances that promote inflammatory reactions. The antiallergic effect develops as a result of a decrease in the synthesis and secretion of allergy mediators.

Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides that acts bactericidal. Gram-negative microorganisms are highly sensitive - Proteus spp. (indole positive and indole negative), Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp., Staphylococcus spp. (methicillin resistant). Sensitive: Enterococcus faecalis, Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp. Resistant: Neisseria meningitidis, Treponema pallidum, anaerobic microbes: Streptococcus spp. (except Streptococcus pneumoniae), Enterococcus faecalis Providencia rettgeri.

Clotrimazole is an antifungal agent from the group of imidazole derivatives for topical use. It acts by disrupting the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Has a wide spectrum of action. Active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (Candida spp., Torulopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).

Indications for use

Simple and allergic dermatitis (especially complicated by secondary infection), atopic dermatitis (including diffuse neurodermatitis), limited neurodermatitis, eczema, dermatomycosis  (dermatophytosis, candidiasis, versicolor), especially when localized in the inguinal region and large skin folds.

Contraindications

Hypersensitivity to any of the components of the drug, skin tuberculosis, skin manifestations of syphilis, chicken pox, herpes simplex, skin post-vaccination reactions, open wounds, childhood.

Method of administration and dosage

Outwardly.

Apply a thin layer to the entire affected skin surface 2 times a day. The duration of treatment is determined individually and depends on the nosological form and severity of the disease. If clinical improvement does not occur in the near future, it is necessary to clarify the diagnosis or change the treatment regimen.

Special instructions and precautions Before using the drug, consult a doctor! Avoid contact with eyes.

Prolonged topical use may lead to the growth of resistant microflora. You should stop the drug, prescribe appropriate therapy.

Avoid application to open wounds and damaged skin.

With prolonged use of the drug, it is recommended to cancel it gradually.

Use during pregnancy and during breastfeeding

Use during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.

Interaction with other medicinal products

Interactions of the drug with other drugs have not been identified.

Side effect

Itching, burning sensation, tingling sensation, urticaria, dry skin, peeling, erythema, exudation, pigmentation disorders, folliculitis, development of a secondary infection, Cushing's syndrome, blistering, local edema, prickly heat.

If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms: with prolonged use of the drug, suppression of adrenal function is possible with the development of secondary adrenal insufficiency and symptoms of hypercortisolism, including Cushing's syndrome; growth of insensitive flora.

Treatment: gradual withdrawal of the drug, symptomatic therapy.

Storage conditions

In a dry and dark place, at temperatures below 25°C.

Keep out of the reach of children!

Shelf life

3 years. Do not use aſter the expiry date stated on the packaging.

Vacation conditions Released by prescription.

Release form

30 g of cream in an aluminum tube along with instructions for use in a cardboard box.